Clearance of persistent hepatitis C virus infection using a claudin-1-targeting monoclonal antibody
نویسندگان
چکیده
Laurent Mailly, Fei Xiao*, Joachim Lupberger*, Garrick K. Wilson, Philippe Aubert, François H. T. Duong, Diego Calabrese, Céline Leboeuf, Isabel Fofana, Christine Thumann, Simonetta Bandiera, Marc Lütgehetmann, Tassilo Volz, Christopher Davis, Helen J. Harris, Christopher J. Mee, Erika Girardi, Béatrice Chane-Woon-Ming, Maria Ericsson, Nicola Fletcher, Ralf Bartenschlager, Patrick Pessaux, Koen Vercauteren, Philip Meuleman, Pascal Villa, Lars Kaderali, Sébastien Pfeffer, Markus H. Heim, Michel Neunlist, Mirjam B. Zeisel, Maura Dandri, Jane A. McKeating, Eric Robinet and Thomas F. Baumert
منابع مشابه
Humanisation of a claudin-1-specific monoclonal antibody for clinical prevention and cure of HCV infection without escape
OBJECTIVE HCV infection is a leading cause of chronic liver disease and a major indication for liver transplantation. Although direct-acting antivirals (DAAs) have much improved the treatment of chronic HCV infection, alternative strategies are needed for patients with treatment failure. As an essential HCV entry factor, the tight junction protein claudin-1 (CLDN1) is a promising antiviral targ...
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Claudin-1 (CLDN1), a known host factor for hepatitis C virus (HCV) entry and cell-to-cell transmission, is a target molecule for inhibiting HCV infection. We previously developed four clones of mouse anti-CLDN1 monoclonal antibody (mAb) that prevented HCV infection in vitro. Two of these mAbs showed the highest antiviral activity. Here, we optimized the anti-CLDN1 mAbs as candidates for therape...
متن کاملDiscovery of Anti – Claudin - 1 Antibodies as Candidate Therapeutics against Hepatitis C Virus s
Claudin-1 (CLDN1), a known host factor for hepatitis C virus (HCV) entry and cell-to-cell transmission, is a target molecule for inhibiting HCV infection. We previously developed four clones of mouse anti-CLDN1 monoclonal antibody (mAb) that prevented HCV infection in vitro. Two of these mAbs showed the highest antiviral activity. Here, we optimized the anti-CLDN1 mAbs as candidates for therape...
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Background and aim: An epidemiological association of lichen planus (LP) with hepatitis C virus (HCV) infection has been found only in certain parts of the world and in some countries no association has been noted. The present study was done to evaluate the association of LP with HCV in patients admitted to Sina hospital, Hamedan, Iran from 2002 to 2004.Materials and Methods: The presence of an...
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Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission. In this study we use a novel infectious coculture system to examine these alternative modes of infection. Cell-to-cell transmission is relatively resistant to anti-HCV glycoprotein monoclonal antibodies and polyclonal immunoglobulin isolated from infected individuals, providing an ...
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